The EMC3‐Eirene code is improved in many aspects. Ad hoc boundary conditions for intrinsic impurities at the SOL‐core interface are removed by implicitly coupling to a 1D core model. Non‐uniform cross‐field transport coefficients are allowed in the new code version. A particle splitting technique is implemented for improving the Monte Carlo statistic in low‐temperature ranges of most interest. Domain splitting, which was possible for the toroidal direction only, is now feasible for all three directions, facilitating mesh optimization for any specific divertor configuration. Stellarator‐specific constraints on mesh construction have been relaxed. Axisymmetric neutral‐facing components have been moved to cylindrical coordinates. All these features have improved the code performance and capability significantly. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Diabetes mellitus is a group of complex multisystem metabolic disorders characterized by relative or absolute insufficiency of insulin secretion and/or concomitant resistance to the metabolic action of insulin on target tissues. 1 The worldwide explosion of this chronic ailment is a major health care burden. The number of people globally with diabetes are projected to rise to 439 million (7.7%) by 2030. 2 Currently, India has 41 million diabetics, and this number is expected to increase to 70 million by 2025. The increased number of diabetics in India is likely due to unprecedented rates of urbanization and lifestyle changes. 3 The increased morbidity and mortality of diabetic patients is mostly attributed to complications of the disease. Hyperglycemia is the immediate metabolic consequence of diabetes, and chronic hyperglycemia leads to several events that promote structural changes in tissues. 1,4 A high prevalence of wide spectrum oral alterations associated with diabetes has been described in literature. To minimize the risk of complications associated with this disease, it is necessary to regularly monitor the glucose levels of diabetic patients. The important aspect in glycemic control is the frequent monitoring of blood glucose levels. 5 Various biofluids that are used to monitor glucose levels include blood and urine. The choice of blood as a diagnostic fluid for clinical testing is clear-cut considering its close relationship to the homeostasis of the body. Because blood circulates throughout all organs, its chemical makeup is a composite of nearly all metabolic processes occurring in the 552673D STXXX10.
We developed a versatile and highly sensitive biosensor platform. The platform is based on electrochemical-enzymatic redox cycling induced by selective enzyme immobilization on nano-sized carbon interdigitated electrodes (IDEs) decorated with gold nanoparticles (AuNPs). Without resorting to sophisticated nanofabrication technologies, we used batch wafer-level carbon microelectromechanical systems (C-MEMS) processes to fabricate 3D carbon IDEs reproducibly, simply, and cost effectively. In addition, AuNPs were selectively electrodeposited on specific carbon nanoelectrodes; the high surface-to-volume ratio and fast electron transfer ability of AuNPs enhanced the electrochemical signal across these carbon IDEs. Gold nanoparticle characteristics such as size and morphology were reproducibly controlled by modulating the step-potential and time period in the electrodeposition processes. To detect cholesterol selectively using AuNP/carbon IDEs, cholesterol oxidase (ChOx) was selectively immobilized via the electrochemical reduction of the diazonium cation. The sensitivity of the AuNP/carbon IDE-based biosensor was ensured by efficient amplification of the redox mediators, ferricyanide and ferrocyanide, between selectively immobilized enzyme sites and both of the combs of AuNP/carbon IDEs. The presented AuNP/carbon IDE-based cholesterol biosensor exhibited a wide sensing range (0.005–10 mM) and high sensitivity (~993.91 µA mM−1 cm−2; limit of detection (LOD) ~1.28 µM). In addition, the proposed cholesterol biosensor was found to be highly selective for the cholesterol detection.
Flavonolignans isolated from Hydnocarpus wightiana seeds, namely hydnowightin, hydnocarpin, and neohydnocarpin, demonstrated potent hypolipidemic activity in mice, lowering both serum cholesterol and triglyceride levels at 8 mg/kg/day ip. Hydnowightin demonstrated the best lipid-lowering effect of the three compounds. Good anti-inflammatory and antineoplastic activity was demonstrated by hydnocarpin in mice in vivo. The other two derivatives were not as active in these screens. Cytotoxicity against the growth of murine and human tissue cultured cells was shown. All three compounds were moderately active against murine L-1210 leukemia growth. All three compounds demonstrated good activity against the growth of human KB nasopharynx, colon adenocarcinoma, osteosarcoma, and HeLa-S3 uterine growth. Hydnocarpin was the only compound of the three which was active against glioma growth. Hydnocarpin and neohydnocarpin demonstrated significant activity against Tmolt3 leukemia cell growth.
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