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Se evaluaron los efectos producidos por extractos etanólicos preparados con hojas de Genipa americana L. (Ñandypa) sobre el ciclo replicativo celular utilizando el Allium test y fibroblastos de la línea celular NCTC-929. Se midieron el índice mitótico, índice de fases, la duración del ciclo celular y la citoxicidad metabólica respectivamente. Los análisis demostraron que las células tratadas presentan menor índice mitótico, produciéndose una alteración en el ciclo celular. Se registraron puentes intercromosómicos, fragmentos durante las anafases, y cromosomas adelantados y rezagados.

Introduction:Yerba mate(ilex paraguariensis(IP))is a plant widely consumed in South America as a hot(mate)or cold infusion beverage(tereré). During the last years, there was an increasing interest in its health properties supported by a growing scientific evidence. These studies showed that the IP could have hepatoprotective, hypocholesterolemic, diuretic and antioxidant properties. Furthermore it showed to be a nervous system stimulant and protectant(1). Recently, there were reports about its invitro potential to inhibit the Monoaminooxidase(MAO) which can have effects on mood state(2).Objectives:Exploratory research to study possible associations between the use of IP and mood symptoms.Method:An observational cross-sectional study was conducted by an online survey in paraguayan population through an invitation. The survey collected data information about sociodemographics conditions, substance use(including IP), Spielberg's State-Trait Anxiety Inventory and PHQ-9 scale for depressive symptoms. A descriptive and multiple lineal regression analysis of the data was performed.Results:300 subjects accepted the invitation and information was obtained of about 76% of them. The sample mean age(SD) was 27(7,4), most of them females(61,6%)and with universitary studies(66,1%). The 86% of the sample consumed IP regularly and 56% daily. Only a 3,5% reported previous psychiatric history. A significant relationship was observed between the use of IP and daily alcohol(p=0,022). No relevant associations were found concerning IP use and anxiety trait-state or depressive symptoms after adjusting for the use of coffee, tea, alcohol and others sociodemographic variables.Conclusions:No significant associations were found in the sample studied between the use of IP and state-trait anxiety or depressive symptoms. Although, given the frequency of its use, the association with alcohol consumption and its potential clinical applications, more and bigger studies might be necessary.

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