This study aims to explore the effect of 1) students' mind mapping towards concepts mastery; 2) students' learning styles towards concepts mastery; 3) interaction between mind mapping and learning styles towards concepts mastery and 4) students' mind mapping towards students' representation skills on the respiratory system. The sample of this study was 86 students of class VIII MTs N 1 Pesawaran, which is the selected technique randomly. The research instrument used the pretestposttest to know the students' mastery concepts and representation skills improvement and questionnaires to identify students' learning styles. The design used was a nonequivalent pretest-posttest control group design. Data of students' concepts mastery and representation skills in the form of pretest-posttest and n-gain analyzed using ANCOVA and Least Significant Difference Test (LSD). The results showed 1) students' mindmapping has a significant effect on students' concept mastery. 2) student learning styles have a significant influence on mastery of concepts. 3) there is no significant interaction between mind mapping and learning styles on the mastery of concepts. 4) there is a significant interaction between mind mapping and learning styles on representation skills.