Focal tumor control was performed safely using minimally invasive LITT with real-time MRTI control. LITT could be considered as salvage therapy for high-grade recurrent gliomas if a 1-day treatment is considered useful for a few weeks gain in survival. Larger experience will be required to define indications for such infiltrative disease and accurately determine a potentially significant survival gain in good neurological condition associated with this 1-day procedure.

Sphenoorbital meningiomas are insidious tumors with slow progression. Even when exophthalmos is not clinically evident, it is always present on preoperative MR imaging. Total resection is not possible due to superior orbital fissure invasion, but subtotal resection (Simpson Grade II) can assure long-term stability due to the nonevolutive nature of most residual tumors. Exophthalmos improves at early radiological follow-up, but may worsen again as time passes.

Distinguishing tumor recurrence from radionecrotic injury of pre-irradiated brain metastases is fundamental to provide optimal patient care. Unfortunately, this distinction is often hard to make even with advanced MRI multimodal protocols. This study aims to evaluate APTw imaging in predicting the differentiation between radio-induced tissue changes from tumor progression at 3T in 20 pre-irradiated metastases. Results show that APTw metrics can significantly separate these two common radiological entities (p<0.0001) and suggest the use of fluid-suppressed APTw to reach higher discriminating values.