Estimation of runoff is vital forplanning activities in relation to integrated watershed management and flood protection measures. This research was conducted at one of the catchments in Abbay River (upper Blue Nile River) basin to assess the applicabilityof the Hydrologic Engineering Centre Hydrological Modelling Software (HEC-HMS) modelfor simulation of runoff. It was aimed at selecting the best loss and transform methods in the model, as well as testing the applicability of the calibrated model to ungauged watersheds. Two loss methods such as soil conservation service (SCS) and initial and constant methods with two transform methods including SCS and Clark unit hydrographs were considered in the study for selecting the best combinations applicable in the area. While comparing the simulation results of each combination, better results were obtained in the model set containing the initial and constant loss method and SCS unit hydrograph with a Nash-Sutcliff Efficiency (NSE) of 82.8%, R 2 of 0.83, and 10.71% of relative bias errors, followed by initial and constant with Clarks unit hydrograph, and it can be used for similar ungauged watersheds.

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