IMPORTANCE Estimating glomerular filtration rate (GFR) is useful in many clinical conditions. However, very few studies have evaluated the performance of GFR-estimating equations in older adults at various degrees of kidney impairment. OBJECTIVE To determine the performance of plasma-creatinine-based equations Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI), Lund-Malmö Revised, (LMR), full age spectrum (FAS), and Berlin Initiative Study (BIS) 1 in older adults across a broad spectrum of GFRs. DESIGN, SETTING, AND PARTICIPANTS Single-center cross-sectional study performed in France including 2247 participants aged 65 to 90 years who underwent inulin GFR measurements from July 1, 2003, to July 30, 2017, for suspected or established renal dysfunction, for renal risk, before kidney donation, or after kidney transplant. MAIN OUTCOMES AND MEASURES The main outcome measure was GRF measured by inulin clearance. Equation performance criteria considered bias (difference between estimated and measured GFR), precision (interquartile range of the median difference), and accuracy P 30 (percentage of estimated GFRs lying between [measured GFR-30% of measured GFR] and [measured GFR + 30% of measured GFR]). RESULTS The mean (SD) age of the 2247 participants was 71.5 (5) years and 1192 (53.0%) were male. The difference in median (95% CI) bias was significant between CKD-EPI vs LMR (−4.0 [-4.0 to-3.5 mL/min/1.73 m 2 ; P < .001]) and CKD-EPI vs FAS (-2.0 [-3.5 to-2.5] mL/min/1.73 m 2 , P < .001) but not significant between CKD-EPI vs BIS 1 (0.0 [-1.5 to 0.5], P = .07, Mood test). In patients aged 65 to 74 years with measured GFR<45 mL/min/1.73 m 2 , the difference in median P 30 (95% CI) was not significant between CKD-EPI vs LMR (P = .08) and CKD-EPI vs FAS (P = .48) but significant vs BIS 1 (P = .004, McNemar test). In subjects 75 years and older, with measured GFR less than 45 mL/min/1.73 m 2 , LMR and BIS 1 were more accurate than CKD-EPI and FAS (P 30 = 74.

No abstract

IntRoductIonOxalate, the ionic form of plasma oxalate (POx), is an insoluble end-product of the metabolism of foods derived from various Association between glomerular filtration rate (measured by high-performance liquid chromatography with iohexol) and plasma oxalate Associação entre taxa de filtração glomerular (medida por cromatografia liquida de alto desempenho com iohexol) e oxalato plasmático Introdução: A hiperoxalemia secundária é uma doença multifatorial que afeta vários órgãos e tecidos em pacientes com rins nativos ou transplantados. O oxalato plasmático pode aumentar durante a insuficiência renal porque é eliminado do corpo pelos rins. No entanto, há evidências escassas sobre a associação entre taxa de filtração glomerular e oxalato plasmático, especialmente nos estágios iniciais da doença renal crônica (DRC). Métodos: uma casuística centrada na descrição das variações na apresentação clínica. Foi realizado um estudo piloto a partir da análise transversal com 72 indivíduos. ResumoPalavras-chave: Taxa de filtração glomerular; Hiperoxalúria; Doença renal crônica.