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Abstract:Transurethral enucleation resection of the prostate is safe and feasible for the treatment of symptomatic benign prostatic hyperplasia (BPH). However, long-term results of this treatment in patients with BPH have not been reported. To assess the efficacy and safety of this procedure, this study retrospectively evaluated long-term outcomes in 1400 consecutive patients who underwent transurethral enucleation resection of the prostate for BPH between 2008 and 2014. Patients were followed up at 1, 3, 6, and 12 months, and every year thereafter. At a median follow-up of 70.1 months, mean Qmax increased from 6.43 to 22.1 ml/s and mean IPSS decreased from 22.3 to 2.9. PVR decreased from 123.0 to 12.0 cc, and mean TRUS volume decreased from 65.4 to 21.4 ml (P<0.0000). QOL score improved from 4.96 to 1.0, and PSA concentrations decreased from 6.87 to 0.75 ng/ml (P<0.0000). Complications included bladder neck contracture in 1.0% of patients and urethral stricture in 1.3%. These long-term results showed that transurethral enucleation resection of the prostate is durable, safe, and effective for patients with BPH, with patients not requiring reoperation.

Electrical and electronic waste (e-waste) contains multiple toxic materials. However, there is currently a lack of exposure data on workers in formal recycling plants. This study aims to observe the influence of electronic waste (e-waste) on male's reproductive health and to provide a theoretical foundation for improving the occupational safety. A survey and sample collections were performed based on 210 workers in e-waste recycling plant as the exposure group and 210 residents who worked at the same area but not exposed to e-waste (other jobs) as the control group. Semen sperm analysis and TUNEL assay were applied to detect the apoptotic rate and single comet assay to detect DNA damage. The survey results showed that infertility rate of e-waste recycling workers was significantly higher than that of non-occupationally exposed workers (P < 0.05); e-waste occupationally exposed workers showed markedly higher rate of prostatitis, urethritis, abortion and preterm birth of their spouses (P < 0.05). The percentage of sperm concentration, motile sperm, 'a' level sperm, 'a+b' level sperm and live sperm of the exposure group were higher than control group (P < 0.05). TUNEL assay revealed that the apoptotic rate of sperms in the exposure group was higher too (P < 0.05). Further, the sperm comet length, tail length, tail DNA %, Olive tail moment were significantly different between the two groups (P < 0.05). In general, we concluded that occupational exposure to e-waste led to asthenospermia and increased male infertility. Occupational exposure to e-waste increased the sperm apoptosis rate and sperm DNA damage.