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Cancer is a genetic mutation disease that seriously endangers the health and life of all human beings. As one of the most amazing academic achievements in the past decade, CRISPR/Cas9 technology has been sought after by many researchers due to its powerful gene editing capability. CRISPR/Cas9 technology shows great potential in oncology, and has become one of the most promising technologies for cancer genome-editing therapeutics. However, its efficiency and the safety issues of in vivo gene editing severely limit its widespread application. Therefore, developing a suitable delivery method for the CRISPR/Cas9 system is an urgent problem to be solved at present. Rapid advances in nanomedicine suggest nanoparticles could be a viable option. In this review, we summarize the latest research on the potential use of nanoparticle-based CRISPR/Cas9 systems in cancer therapeutics, in order to further their clinical application. We hope that this review will provide a novel insight into the CRISPR/Cas9 system and offer guidance for nanocarrier designs that will enable its use in cancer clinical applications.

As the second reason of causing death after cardiovascular disease for human being, cancer is damaging people all over the world. Fortunately, rapidly developing in the past decade, nanotechnology has become one of the most promising technologies for cancer theranostics. Recent studies have demonstrated that metal nanoparticles, especially manganese nanoparticles (Mn-NPs), exhibit amazing potential for application in multifarious oncology fields according to their characteristic fundamental properties. Although global scientists have developed a variety of new Mn-NPs and have proved their preponderance in cancer diagnosis and treatment, Mn-NPs are still not approved for clinical use. In this paper, the recent research progress of Mn-NPs in the fields of cancer diagnosis and therapy is reviewed. Besides, the future prospect and challenges of Mn-NPs are discussed to explore wider applications of Mn-NPs in clinic. Here, we hope that this review will show a better overall understanding of Mn-NPs and provide guidance for their design in clinical applications for cancer.