Despite some notable successes in the control of infectious diseases, transmissible pathogens still pose an enormous threat to human and animal health. The ecological and evolutionary dynamics of infections play out on a wide range of interconnected temporal, organizational and spatial scales, which even within a single pathogen often span hours to months, cellular to ecosystem levels, and local to pandemic spread. Some pathogens are directly transmitted between individuals of a single species, while others circulate among multiple hosts, need arthropod vectors, or can survive in environmental reservoirs. Many factors, including increasing antimicrobial resistance, increased human connectivity, and dynamic human behavior, raise prevention and control from formerly national to international issues. In the face of this complexity, mathematical models offer essential tools for synthesizing information to understand epidemiological patterns, and for developing the quantitative evidence base for decision-making in global health.

Summary A wide variety of phenomena of geographical spread can be described in terms of a mechanism of “growth” (e.g. birth, infection) and a “contact distribution” which describes how the locations of the individual(s) involved in a migratory move, or infection at a distance, are spatially related. I shall survey work on such models, beginning with an examination of the relations between stochastic and deterministic models; it emerges that both linear and nonlinear deterministic models have close connections with the less interesting “linear” (exponential growth) stochastic models. More realistic models must be nonlinear as well as stochastic; some results are now available for such models. As in the linear case, these deal mainly with asymptotic behaviour. Simulations reveal that nonlinear stochastic processes have a richer spectrum of non‐asymptotic behaviour than linear models, though in some circumstances the simpler models may provide an adequate approximation. Thus theoretical study of the short‐term behaviour of such processes may be difficult, but should prove rewarding. The other main outstanding problems are those of inference for such models, especially the estimation of contact distributions.

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