Purpose To evaluate the efficacy and safety of umbilical cord serum eye drops for dry eyes in ocular Stevens-Johnson Syndrome (SJS). Patients and Methods A pre-post test study with umbilical cord serum (UCS) eye drop for ocular SJS patient with moderate to severe dry eyes. Study was conducted at Kirana Cipto Mangunkusumo General Hospital from June 2020 to December 2020. A total of five patients (five eyes) with a diagnosis of SJS more than 6 months, dry eye symptoms, and abnormal tear stability test results were included in the study. Each patient was asked to instill UCS drop into the affected eye six times daily. Evaluation of ocular symptoms with ocular surface disease index (OSDI) questionnaires, non-invasive tear break-up time (NIBUT), Schirmer I, and keratoepitheliopathy scores was administered before applying UCS drop and at week 2 and 4 of eye drop use. Results From June 2020 to December 2020, five eyes of five patients were evaluated in this study. Patients were aged from 22 to 71 years old with history of SJS over periods from 1 to 35 years. Three patients underwent ocular surgeries prior to the study. After four weeks of treatment, symptoms score, Schirmer I, and keratoepitheliopathy scores improved significantly, while NIBUT scores improved insignificantly. No side effects were noted during treatment. Conclusion Administration of UCS eye drop was effective in improving symptoms and signs of dry eye in chronic SJS patients.

Objective: To evaluate and compare the efficacy and safety between endoresection and proton beam radiotherapy, as primary treatment in choroidal melanoma.Methods: Articles that were published from 2008 to 2018 were collected from multiple sources including Pubmed, Clinical Key, and Ophthalmology Advance. All study that comply with the inclusion and exclusion criteria were categorized based on level of evidence Oxford Center for Evidence-based Medicine Levels of Evidence. Primary outcome is secondary enucleation. Secondary outcomes are metastasis, recurrence, death, visual outcomes, and complication. Result: Twelve articles were eligible to be reviewed. Mean secondary enucleation, metastasis, and death rate is lower in endoresection group (6.29% vs 12.94%; 8.00% vs 20.85%; 6.86% vs 20.43) while recurrence rate is lower in proton beam group (4.78% vs 6.86%). The most common complication that observed is retinal detachment. Other complications that were reported includes cataract formation, radiation retinopathy, neovascular glaucoma, vitreous hemorrhage, elevated intraocular pressure (IOP), iris neovascularization, and optic neuropathy. Conclusion: Endoresection as primary treatment for choroidal melanoma shows better efficacy compared to proton beam therapy, regarding the ability to preserve the eyeball. The safety between endoresection and proton beam therapy, both therapy shows similar result.