The aim of this study was to conduct a systematic review that reported the medicinal use of the genus Piper, and pharmacological elucidations for the treatment of symptoms and processes of inflammation and inflammatory diseases. The systematic review was prepared in accordance with PRISMA guidelines. The databases used for this research were the Web of Science and Scopus, where associations with the terms were applied in both databases: "Piper" and "Ethnobotanical" and "Piper" and "Anti-inflammatory effect". Initially, the research identified 153 articles, of which 24 articles were selected for final analysis following the inclusion criteria. The results indicate that the medicinal use of species of the Piper genus entails mainly using of leaves, roots, and fruits, and decoct, maceration and powder for the treatment of inflammatory and respiratory diseases such as asthma and bronchitis. Regarding the evaluation of the anti-inflammatory effect of the genus, only seven species presented studies with their scientifically proven anti-inflammatory effect. Biases in the methodology applied in the studies were observed. In this systematic review, it was noticed that both studies addressed have gaps that can cause damage to future research and that pharmacological studies for inflammation with the use of the species themselves are still limited, with a more job for the isolated compounds of these plants.
Nos últimos anos, a incidência de infecções fúngicas tem aumentado intensamente. As leveduras de Candida são responsáveis por uma ampla variedade de manifestações clínicas, desde infecções do trato urinário até infecções da corrente sanguínea. Uma alternativa aos medicamentos estão os óleos essenciais e seus compostos bioativos, os quais podem apresentar amplo espectro antimicrobiano. Existe uma grande quantidade de trabalhos na literatura que abordam a atuação de óleos essenciais de espécies vegetais como fontes potenciais de agentes antimicrobianos, incluindo a ação anti-Candida. As espécies de Lamiaceae são ricas em óleos essenciais, os quais apresentam substâncias promissores na inibição de Candida. Esta revisão levantou os artigos publicados nos últimos cinco anos (2016 a 2021) com as principais atividades anti-Candida dos óleos essências dos representantes de Lamiaceae, além de ressaltar seus componentes majoritários. A revisão constou de dados obtidos de 56 artigos os quais incluía 71 plantas de Lamiaceae. Os óleos essenciais das espécies mostraram boa atividade anti-Candida (CIMs <1000 µg/ mL). Os principais gêneros trabalhados foram: Thymus (14 artigos), Lavandula (7), Origanum (5) e Salvia (5). Os componentes majoritários encontrados nos óleos incluem timol (23 trabalhos), carvacrol (20), p-cimeno (17), linalol (10), 1,8-cineol (8), γ-terpineno (8) e α-pineno (8) como principais substâncias. Os óleos essenciais podem representar um importante achado no controle de fungos multirresistentes a medicamentos.
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