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Promoting the use of research-based knowledge in public health becomes more complex when public health includes interventions on health determinants. This article examines strategies for knowledge synthesis, translation and exchange (KSTE) in the context of public health in Canada, making reference to the work of the recently established National Collaborating Centres for Public Health (NCCs). NCCs simultaneously pursue KSTE and study how KSTE strategies meet different needs. Because NCCs are focused on interventions and policies, they must address the relationship between knowledge and policy, and how amenable it is to change. KSTE can seek to respond to and inform an existing policy agenda, but it can also seek to shape, frame and change that agenda. The two paths might call for different approaches, and for expanding the boundaries of KSTE in health.

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