Greenhouse and field experiments were conducted in North Dakota to determine the effect of adjuvants applied with imazapic on the control of leafy spurge and production of various grass species and to determine the most effective fall-application timing of imazapic for optimum leafy spurge control with minimal effect on herbage. Imazapic applied with a methylated seed oil (MSO) adjuvant tended to provide greater leafy spurge control than when applied with other types of adjuvants. Imazapic applied alone or with adjuvants reduced production of some grass species in the greenhouse, but it did not decrease herbage production in the field. Imazapic at 140 g/ha applied with MSO or with 28% N plus MSO averaged 72% leafy spurge control 12 mo after treatment, compared to 33% control from imazapic alone and 40% control from picloram plus 2,4-D. Imazapic at 140 g/ha applied with MSO in mid-September provided greater leafy spurge control compared to August or October applications.