To evaluate the efficiency of photobiomodulation therapy (PBMT) in the midpalatal suture (MPS) and pain sensation in patients undergoing rapid palatal expansion (RPE). Thirty-four individuals with the diagnosis of skeletal maxillary hypoplasia were divided in two groups: laser (n = 18) and control (n = 16). Treatment plan consisted of the use of the Hyrax expander in all patients. Subjects in the laser group were irradiated with diode laser (980 nm, 0.3 W) in six spots bilaterally distributed along the MPS for 10 s during the active phase of treatment and after overcorrection (passive phase of RPE). Control group received sham irradiations with the laser in standby mode to characterize the placebo effect. Digital occlusal radiographs were performed at different time-points for bone formation evaluation in both groups. The effects of laser irradiation on pain were assessed by the visual analog scale (Wong-Baker Faces Pain Scale). Bone formation between groups was not significantly different (p = 0.2273). At 3 months, bone formation was not yet complete in both groups. Pain sensation was similar between groups (p = 0.3940). However, pain was significantly higher for the first 7 days of treatment compared with the 14th day. PBMT did not accelerate bone regeneration in the MPS and pain sensation was similar.

The treatment effect against psoriasis of an antigen (delipidated, deglycolipidated form of M. vaccae-PVAC) was investigated. One hundred and sixty-five patients were enrolled in three arms (50 or 15 microg or placebo), each receiving a total of two intradermal injections (days 0 and 21). At week 12, a 75% decrease in psoriasis area and severity index was similar among the studied groups (13, 9 and 18%, p=0.429). The overall incidence of adverse events was significantly higher in the PVAC treated groups when compared to placebo (98.2, 87.3 and 70.9%; p<0.001) largely due to local reactions that were limited for the most part to grades 1 and 2 in severity and were self-limiting. Despite its overall safety, PVAC was not clearly indicated to be superior to placebo in the treatment of psoriasis in this study.

The world is moving towards a low-carbon economy through renewable energy sources. In this context, concentrating solar power (CSP) technologies can exploit the rich solar resource in Brazil, diversifying the national electricity mix. The aim of this paper is to support the insertion of CSP generation in the Brazilian bottom-up model MATRIZ by analyzing the environmental performance of three CSP technologies: (i) solar tower power (STP) with a thermal storage system (TSS) of 7.5 h; (ii) solar thermal parabolic trough (STPT) with a TSS of 6 h; and (iii) STPT without TSS. From a life cycle perspective, their freshwater consumption and greenhouse gas (GHG) emissions are addressed by employing the software SimaPro, the Ecoinvent database, and the ReCiPe 2016 method, as well as information from the system advisory model (SAM) and the literature. As a result, STP is the most environmentally sound CSP alternative, presenting lower GHG emissions and water consumption than the two STPT technologies. In general, CSP generation proves to be more environmentally attractive than some fossil-fired power plants and renewable energy sources. Moreover, moving the manufacturing of CSP technologies to Brazil has the potential to reduce GHG emissions from the upstream processes of their value chain.

The sustainable development paradigm has been encouraging the current worldwide transition from fossil fuels torenewable energy sources and a more balanced approach to the social-environmental concerns against economic hegemony, which implies changes in how decision-makers design the future electricity system. In this context, this paper explores the integration of the Life Cycle Sustainability Assessment (LCSA) with a Multicriteria Decision Making (MCDM)method, named Simple Multi-Attribute Rating Technique Exploiting Ranks (SMARTER), in order to analyze and compare the sustainability performance of the current electricity mix with different future scenarios in Brazil, reported by The Brazilian Ten-Year Energy Expansion Plan 2027. This analysis considers nine criteria distributed into environmental, social,and economic dimensions of sustainability obtained from different sources, such as literature, the Ecoinvent 3.5 database, and calculated by ReCiPe 2016 and USEtox 2 methods. According to the results, the current electricity mix presents the best social and economic performance, and its environmental performance will enhance in the future, mainly due to the expansion of some renewable energy sources. Concerning the future scenarios investigated, the results indicate that those with greater participation from these energy sources are associated with the best sustainability performance. However, it isworth pointing out that these results do not represent the most suitable Brazilian electricity mix path. Besides the criteriaconsidered in this paper, it is influenced by other factors, such as technical, geographical, and national policy. Furthermore, assuming different suppositions and system boundaries for energy sources and technologies might significantly vary our findings.