BackgroundThis study aimed to evaluate the effect of the intake of yerba mate (YM) and green tea (GT) on serum levels of leptin and paraoxonase-1 (PON-1), compared to control.MethodsControlled, randomized clinical trial (RCT) that evaluated 142 men and women affected by overweight or obesity aged 35–60 years, untreated dyslipidemia and no history of coronary artery disease. Participants were randomized to ingest 1000 mL GT, YM or apple tea (AT, control group) daily, during eight weeks. Serum PON-1 and leptin levels were analyzed by ELISA immunoassay at the beginning (baseline) and after eight weeks of intervention.ResultsThe intake of 1 l of YM/day resulted in significant increase in serum levels of PON-1 (9.7%; p = 0.005). The consumption of GT induced no significant difference in the levels of PON-1 (p = 0.154) and leptin (p = 0.783). Intergroup analysis showed a significant difference (p = 0.036) in the variation of PON-1 levels in the YM group when compared to GT and AT groups. In addition, the increase in PON-1 levels in the YM group was significantly associated with increased HDL-c (p = 0.004).ConclusionsThe intake of yerba mate increased the antioxidant capacity by increasing serum levels of PON-1 and was positively associated with increased HDL-c, stressing the protective role of this beverage against atherosclerotic diseases. GT intake had no significant effect on serum levels of PON-1 and leptin.Trial registrationThis study is registered with ClinicalTrials.gov under protocol number NCT00933647.
BackgroundExcessive weight is a cardiovascular risk factor since it generates a chronic
inflammatory process that aggravates the endothelial function.ObjectiveTo evaluate the endothelial function in individuals with excess weight and
mild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), and
the association of endothelial function with anthropometric and biochemical
variables.MethodsCross-sectional study that included 74 individuals and evaluated
anthropometric variables (body mass index [BMI], waist-hip ratio [WHR],
waist circumference [AC], and percentage of body fat [PBF]), biochemical
(blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen,
total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) and
endothelial function (BAFMD, evaluated by ultrasound). The statistical
analysis was performed with SPSS, version 16.0. To study the association
between the variables, we used chi-square, Student's t and Mann-Whitney
tests, and Pearson's correlation. Logistic regression analyzed the
independent influence of the factors. Values of p < 0.05 were considered
significant.ResultsThe participants had a mean age of 50.8 years, and 57% were female. BMI, WC,
WHR, and PBF showed no significant association with BAFMD. The male gender
(p = 0.02) and higher serum levels of fibrinogen (p = 0.02) were
significantly and independently associated with a BAFMD below 8%.ConclusionsIn individuals with excess weight and mild untreated dyslipidemia, male
gender and higher levels of fibrinogen were independently associated with
worse BAFMD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.