Highlights d Stress-inducible TIMP2 is a bona fide co-chaperone of extracellular HSP90 (eHSP90) d TIMP2 regulates HSP90 chaperone function and interaction with client MMP2 d Secreted co-chaperones TIMP2 and AHA1 displace each other on the eHSP90:MMP2 complex d TIMP2-AHA1 competition impacts client MMP2 activity and matrix gelatinolysis

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Highlights Clear cell adenocarcinoma of the lower urinary tract is rare and poses diagnostic challenge. GATA3, which is frequently expressed in urothelial carcinoma, can be expressed in clear cell adenocarcinoma. ARID1A, PBRM1, ERBB4, and SMARCA4 mutations were identified in the current CASE. Molecular studies may aid in the diagnosis, and optimal treatment decision-making process.

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