P urpose: P olycystic ovary syndrom e (P C O S) is an endocrine disease characterized by chronic anovulation and hyperandrogenism . H orm onal changes can affect tear function. T his study evaluates tear function and im pact of hyperandrogenism on it in P C O S patients. M ethods: F ifty patients w ith P C O S and thirty control volunteers w ere exam ined for tear break-up tim e, Schirm er-I and tear osm olarity. A lso, serum levels of total testosterone, F SH , L H and A M H w ere determ ined in venous blood sam ples in the early follicular phase. P C O S patients w ere divided into tw o groups by plasm a total testosterone level: G roup A w ith norm al (0.513 ng/m l;n= 27), G roup B w ith higher horm one level (> 0.513 ng/m l;n= 23). H ealthy control group indicated as G roup C (n= 30). R esults: L H , total testosterone levels w ere higher in the P C O S group than in the control group (p= 0.012;p= 0.025). M ean values of tear break-up tim e and Schirm er-I w ere different betw een groups and especially G roup A and C w ere near to each other differing from B (p> 0.05). Tear osm olarity results w ere higher in G roup B , com pared to A and C (p= 0.049;p= 0.033). N o significant difference detected in tear osm olarity value m eans of G roup A and C (p= 0.107). A M H levels w ere higher in G roup B , com pared to A and C (p= 0.002;p= 0.001). A M H levels in G roup A w ere higher than that of C (p= 0.002). P ositive correlation betw een levels of total testosterone and A M H w as detected in all P C O S patients (n=. U m a correlação positiva entre os níveis de testosterona total e A M H foi detectada em todas as pacientes com SO P (n = 50;P earson's r = 0,579; p < 0,001). C onclusão: a função lacrim al pode ser afetada em pacientes com SO P com hiperandrogenism o. A osm olaridade lacrim al é o m étodo de avaliação m ais sensível e objetivo para alterações da superfície ocular em SO P. D escritores: Síndrom e dos ovários policísticos; L ágrim as / fisiologia; C oncentração osm olar; H iperandrogenism o; H orm ônio anti-m ülleriano

Background: Blunt eye trauma is an important emergency in ophthalmology practice, and may alter the structure of the macula. Objectives: To evaluate the optic coherence tomography (OCT) measurements of central macular thickness (CMT) among patients admitted to the hospital within 48 hours of blunt eye trauma. Methods: Prospective cross-sectional study to evaluate patients who were admitted to hospital with blunt eye trauma within 48 hours trauma. Spectral domain OCT was used to measure macular thickness. CMT measurements of 24 healthy and 26 traumatized eyes of same patients were analyzed as control and case groups, respectively. Results: The mean CMT measurements were 230.04 ± 18.64 μm in control and 226.50 ± 18.89 μm in traumatized groups. The difference between two groups was not statistically significant (P = 0.412). However, when the patients were classified according to the severity of trauma, CMT measurements of severely injured patients were found significantly lower than both healthy and mildly traumatized eyes (P = 0.008, P = 0.004, respectively). Conclusions: Early stage macular OCT findings at blunt eye trauma may change with the severity of trauma. We have determined an insignificant increase in the mildly traumatized group in CMT compared with the healthy group within the first 48 hours of blunt trauma as a sign of macular trauma. However, in the severely traumatized group in CMT values significantly decreased, which may be a sign of cellular loss. Further prospective studies with long follow-up periods are warranted to elucidate the effects of this decrease in thickness.