. Seropositivity was significantly varied with sex and district of cattle (P < 0.05). The odds of being seropositive for female cattle was observed to be 2.05 times of the male cattle (OR; 2.05, 95% CI: 1.22 -3.43) and Cattle from Sayo district had significantly higher seroprevalence than dale sadi cattle (OR; 2.58, 95% CI: 1.37 -4.87). In conclusion, the result of this study showed that FMD is an important cattle disease in the study area necessitating further investigation and characterization of the circulating virus serotype to apply effective control and prevention measures.