This study has identified T1R as being under-diagnosed in comparison with clinical assessments. Key variables for diagnosing T1R were established. This comparative masked study highlights the need for such studies in other inflammatory conditions.

The fi rst recorded autopsy fi ndings are presented on a young person suffering from intractable lepra reaction treated for four months with clofazimine in a dose of 300 mg daily. Apart fram a generalized yellow colouration of fa tty tissue, brick red in muscle and viscera , extreme congestion and oedema of the mucosa of the small intestine was found, and considered not to be caused by any infectious agent. Deposits of clofazimine crystals were found in the intestinal mucosa .

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A histopathological study of the tongue lesions in 8 cases of lepromatous leprosy is presented. The salient histopathological changes in these lesions are described and the implication of the findings discussed.

A quantitative assessment of clofazimine in some of the organs obtained at autopsy is reported. Although 40 days had elapsed since stopping treatment with the drug, significant quantities of the substance were found in the organs of the reticulo-endothelial system. The intestinal mucosa ais o showed a heavy con centration of the drug. Attention is drawn to the heavy accumulation of the drug during prolonged treatment.