The main aim of the pharmacist is to provide the right drug in the right quality at the right time to patient. The monitoring studies of such prescription pattern can nourish the relevant use and exploit or misuse of the drug which is monitored. The main goal of the present study is to ease the rational use of drugs and make awareness of the irrational use of the drug which is more prevalent to the drug resistance, economic burden to the patient and failure of the treatment. The present prospective observational study was going on the usage of anti-infective agents in the adults based on the prescription of the physician to the patients. Prescriptions were obtained from various clinical departments was done over the period of 6 months from October 2020 to March 2021 to assess the appropriate use of anti-infective agents in adults. Total 1610 prescriptions data of anti-infective agents were analysed of average range of medication includes antibacterial, antiviral, antifungal, anthelmintic, antiparasitic, antimicrobials. A total of 1610 prescriptions from out patient and in patient department of the hospital were analysed in this study and out of those patients, male patients were 714 (44.34%) and female patients were 896 (55.65%). The most common age group which was prescribed more antiinfective agents was 51-60 years. Among them the antibacterial were about 65.03%, antiviral 1.59%, antifungal 7.04%, anthelmintic 7.09%, antiparasitic 0.89%, antimicrobial 0.51%, antimalarial 0.93%, antitubercular 0.51%, Antibacterial+Antiprotozoal 16.45%. Now a days usage of anti-infective agents was high to improve the rational use of drugs and to avoid the irrational usage of antibiotics in increasing the side effects and resistance towards the drug and total cost of treatment as well.