Background: The genus Clerodendrum is among the most important in the plants' kingdom with many species known for their medicinal properties and among which is well represented. Previous studies Clerodendrum thomsoniae established hypolipidemic, antioxidant and antidiabetic properties of aqueous extract (AECT) of Clerodendrum thomsoniae.This study aimed at evaluating the effect of the AECT on the onset of hyperlipidaemia in wistar Objective: rats.Normal Wistar rats were administered AECT (312.5, 625 and 1250 mg/kg, p.o.) followed Material and methods: by feeding with high fat diet for five weeks. Lipid parameters such as total cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) levels were measured in serum. The modifications in the body mass, feed intake were evaluated. The results revealed that HFD induced an alteration in serum, lipid profile (triglyceride, cholesterol, HDL, and LDL) in negative control rats. Meanwhile in rats subjected to AECT (312.5, 625 and 1250 mg/Kg p.o) no significant changes were noticed with the normal control rats (p 0.05). On the other hand, concerning body mass, no significant change was observed between the normal control < and test rats. AECT showed the ability to prevent the onset of hyperlipidaemia in rats. Hence, it could be used in the management of cardiovascular diseases, obesity and metabolic syndrome.