Herein, we report the green and efficient synthesis of some pharmacologically important azomethine derivatives of isoniazide (INH) using Modified Fly Ash (MFA) as an excellent zeotic solid acid catalyst.

Abstract:: Now days, it is of utmost important to design synthetic methods; which can be utilized for the generation of substances that will minimize toxicity to health of human and the environment. The utilization of acid catalysts generates lots of corrosive and harmful wastes which has to be treated with appropriate alkalis. Hence, it generates lots of sludge and alarms environmental issues of its storage and disposal. Zeolites and Zeotypes; by virtue of their peculiar properties; such as specific morphology, porosity and residing acidity; attracting enormous attention as they replaces harmful acid catalysts efficiently and also reduces chemical waste in industrial process; Hence emerged as new plethora in the field of “Green Chemistry”.

Azomethine is the key linkage in all Schiff base reactions. The present context has efficiently emphasized on the utilization of Schiff base strategy effectively in the synthesis of polyazomethine polymer gel materials. The synthesized polymer gel is characterized by different physical techniques for testing its proper existence such as FESEM analysis, thermal gravimetric analysis, differential scanning calorimeter analysis, FTIR analysis and electron dispersive X-ray scattering analysis. The morphological study has revealed that the material is having 3D lamellar-layered architecture, i.e., layerby-layer array of polymer chains. The synthesis governs several advantages, such as executing without using any catalyst and water as a green solvent. The present study also checked its complexion ability with nitro aromatic acceptors. The intercalation of nitro aromatic molecule between the two straight chains of the polymer gel is the beautiful peculiarity of these red-coloured complexes.

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