Background : diabetes mellitus (DM) is associated with increased total cholesterol and triglyceride, also well characterized by increased malondialdehyde production. β-carotene has antioxidant activity, glycemic and lipid control. Objective : to analyze the effect of β-carotene on total cholesterol, triglyceride and MDA on diabetic Rattus norvegicus sprague dawley. Methods : thirty rats were randomly divided into 5 groups : 1 (STZ), 2 (STZ+β-carotene 1 mg/kg BW), 3 (STZ+β-carotene 10 mg/kg BW), 4 (STZ+β-carotene 20 mg/kg BW), 5 (normal). Streptozotocin induced intraperitoneal 40 mg/kg BW. β-carotene was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP, total cholesterol by CHOD-PAP, triglyceride by GPO and MDA by ELISA with TBARS methods. Hypothesis test used one way anova then followed by post hoc bonferroni to analyze the efficient dose effect. Results : there was a significant difference of total cholesterol (p=0.002) after β-carotene 10 mg/kg BW supplementation on alternate days within 30 days orally. β-carotene 10 mg/kg BW was the most efficient dose to lowering total cholesterol. There were significant differences of triglyceride (p=0.0001) and MDA (p=0.0001) after β-carotene 1, mg/kg BW, 10 mg/kg BW and 20 mg/kg BW supplementation on alternate days within 30 days orally. β-carotene 10 mg/kg BW was the most efficient dose to lowering triglyceride, while 20 mg/kg BW to lowering MDA. Conclusion : β-carotene 10 mg/kg BW is the most efficient dose to lowering total cholesterol and triglyceride. β-carotene 20 mg/kg BW is the most efficient dose to lowering MDA.
Penelitian ini bertujuan untuk menjelaskan dan mendeskripsikan fungsi Masjid Al-Hakim di kawasan wisata Pantai Padang yang dimanfaatkan oleh pengunjung dan masyarakat. Penelitian ini dianalisis menggunakan teori struktural fungsional dari Robert K Merton yaitu fungsi manifest dan fungsi laten. Penelitian ini menggunakan pendekatan kualitatif dengan tipe penelitian studi kasus. Pemilihan informan menggunakan teknik purposive sampling dengan informan berjumlah 12 orang yaitu 1 pengurus masjid, 1 petugas keamanan, 8 pengunjung dan 2 fotografer amatir. Teknik pengumpulan data yang digunakan adalah observasi, wawancara dan studi dokumen. Untuk memeriksa keabsahan data peneliti menggunakan triangulasi data dan data dianalisis dengan menggunakan analisis model Milles dan Huberman yaitu reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa Masjid Al-Hakim dimanfaatkan oleh pengunjung dan masyarakat sebagai tempat ibadah, tempat memberi jaminan sosial atau bantuan sosial kepada masyarakat, tempat membantu ekonomi masyarakat, tempat persinggahan, tempat wisata, lokasi foto dan sebagai tempat berkumpul atau ruang publik
Simplisia merupakan bahan alami sebagai bahan pembuatan obat yang belum mengalami pengolahan. Pengirisan merupakan salah satu tahap penting dalam pembuatan bahan simplisia untuk mempermudah dalam proses pengepakan, penyimpanan dan penggilingan. Pengirisan dapat dilakukan secara melintang atau membujur. Tujuan penelitian ini adalah mengetahui pengaruh arah dan tebal irisan rimpang terhadap rendemen flavonoid, berat kering dan performa simplisia umbi garut (Maranta arundinaceaL.) setelah pengeringan. Penelitian ini dilaksanakan di Laboratorium BSF Tumbuhan UNDIP. Rancangan yang digunakan adalah Rancangan Acak Lengkap (RAL) pola faktorial 2X2 dengan perlakuan kombinasi ketebalan (3 mm dan 5 mm) dan arah irisan (membujur dan melintang). Parameter penelitian meliputi berat kering dan performa simplisia yang meliputi warna, kekerasan, dan aroma pada simplisia kering. Analisis data menggunakan Anova dengan taraf kepercayaan 95%. Hasil penelitian menunjukkan arah irisan berpengaruh terhadap berat kering simplisia, sedangkan interaksi antara tebal dan arah irisan tidak berpengaruh terhadap berat kering simplisia umbi garut. Arah irisan berpengaruh terhadap berat kering dan performa simplisia umbi garut, tebal irisan berpengaruh terhadap rendemen flavonoid. Crude simplisia is natural material for making medicine, which has not undergo processing, packing, drying and saving. Slicing is an important step in making medicine because in this process the loss of some parts could ease the process of packing and milling. Slicing could be done diagonally or longitudinally. A Different way of slicing could affect this simplisia. This study aimed to examine the influence of slicing direction, the thickness of slices, and its combination on the dry weight and the performance of arrowroot. This research was conducted in the Laboratory of BSF Tumbuhan UNIDIP. The design used was Completely Randomized Design with combination treatment of thickness (3mm and 5mm) and slice direction (diagonally and longitudinally). The parameter of this research used dry weight by weighing after the drying process and the performance (by measuring color, hardness, and the aroma of dried simplisia). The data analysis used Analysis of Variance. The findings showed that slice direction influenced the weight loss on simplisia, but the interaction did not influence on the dry weight of arrowroot simplisia. Slice direction affects dry weight and performance of arrowroot simplicia, slice thickness affects flavonoid yield.
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