The aim is to analyze the relationship between the personality traits of nursing students and their attitudes toward people with mental illnesses. Design and Methods:The cross-sectional study constituted of 281 students.The Community Attitudes toward the Mentally Ill Scale and the Ten-Item Personality Inventory were used. Findings:The students who have mental illnesses or in their families showed a higher goodwill score. The openness to experience subscale was correlated with conscientiousness, extraversion, emotional stability, and agreeableness.Practice Implications: Organizing educational programs for nursing students focusing on developing a positive attitude toward people with mental illnesses is crucial.