Perfluoroalkyl groups containing bicyclo[1.1.1]pentanes (BCPs) are of increasing interest in pharmaceutical industry and material science; however, the development of an efficient methodology to construct perfluoroalkylated BCPs remains a challenging task....

Herein, we report the metal-free synthesis of methylenecyclobutane containing tetrasubstituted alkenyl nitriles via a strain-release driven addition reaction of [1.1.1]propellane under mild conditions. Using this strategy, TMSN3 was shown to...

Bicyclo[1.1.1]pentanes (BCPs) are significant motifs used as linear spacer units to enhance pharmacokinetic profiles in modern drug design. Herein, we report a novel cascade multicomponent reaction for the synthesis of...

Herein, we report a catalyst-free synthesis of C3-halo substituted bicyclo[1.1.1]pentylamines under mild conditions. The reaction involves the use of sodium hypohalites and sulfonamides to generate N-halosulfonamides in situ, which subsequently...