Objective To determine whether risk factors other than hyperglycemia lead to failed osseointegration in patients with type 2 diabetes mellitus (T2DM) during the healing period. Materials and Methods We compared the success rates between patients with and without T2DM during the healing period at our center. Bone marrow mesenchymal stem cells (BMSCs) were cultured from subjects. Proteomics was used to detect differentially expressed proteins (DEPs) among the DM failure (DM‐F), DM success (DM‐S), and control (Con) groups. The correlation between the expression levels of nine target DEPs and medium glucose concentrations was investigated. Results Higher failure rates were observed in the T2DM patients. Fifty‐two DEPs were found between the DM‐F and DM‐S groups. Seventy‐three DEPs were found between the DM‐F and Con groups. Forty‐three DEPs were found between the DM‐S and Con groups. Five target DEPs were expressed at the same levels in the medium with different glucose concentrations. Gene ontology annotation and functional enrichment analysis suggest that the DEPs detected in the DM‐F group may affect the biological function and regulatory potential of BMSCs. Conclusions The DEPs detected in the DM‐F group can be intervention targets for to prevent implant failure in T2DM patients. Risk factors besides hyperglycemia may affect osseointegration during healing period.

It was concluded that anthropophobic subjects' early sexual experiences and need for parental approval shaped their conformity to social norms and negative sexual attitudes, which were reinforced by the collective-orientated cultural environment, and contributed to the development of anthropophobia.

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Background: It is commonly accepted glycemic control can decrease the negative effects of implant in type 2 diabetes mellitus (T2DM) patients. Whether the remaining pathological changes besides hyperglycemia caused by T2DM will affect implant-bone integration during the healing period has remained unclear. This study aims to determine whether other risk factors besides hyperglycemia lead to failed osseointegration in T2DM patients during healing period. Methods: First, we compared the success rate between T2DM patients and non-T2DM patients during the healing period at our center. Bone marrow mesenchymal stem cells (BMSCs) were cultured from all enrolled subjects. Then, proteomics was used to detect differentially expressed proteins (DEPs) among the DM failure (DM-F), DM success (DM-S) and control (Con) groups. Additionally, the relationship between expression of the nine target DEPs and glucose concentration in media was investigated. Results: Significantly higher failure rates in T2DM patients were found. Fifty-two DEPs were found in DM-F group compared with DM-S group. Seventy-three DEPs were found in DM-F group compared with the Con group. Forty-three DEPs were found in DM-S group compared with Con group. Four target DEPs was influenced by glucose, while the other five expressed the same in different glucose concentration media. DEPs in DM-F group may affect the biological function and regulatory potential of BMSCs through gene ontology annotation and functional enrichment analysis. Conclusions: DEPs in DM-F group can be potential risk factors and intervention targets for dental implant in T2DM patients. More potential risk factors affect implant-bone integration besides hyperglycemia.