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Acute febrile illness, hypertension, diabetes mellitus. Aims And Objectives:The present study aims to document the antibiotics used in Acute febrile illness. 1. To identify the different antibiotics used in acute febrile illness. 2. To find out the epidemiology of antibiotics and their combination in diagnosed condition. 3. To find out the epidemiology of co morbid condition. 4. Patient knowledge after counseling. Method:An observational, prospective cohort study was conducted at a tertiary care teaching hospital in Hyderabad, T.S, India. A total of 200 patients from the inpatient department of general medicine in Aware Global Hospital, who were prescribed antibiotics and those who fulfilled the exclusion and inclusion criteria were selected for the study which was conducted for 6 months. All information significant to the study was collected from the case records and discussions conducted with the in-patients and bystanders during ward rounds, with the support of a physician, which were analyzed by SPSS and Chi-square method. Moreover, daily follow-ups were conducted to assemble data on amendment in therapy, add-on therapy, and clinical improvement. Results:The mean age was 41years and standard deviation was 18years of this population. 57% were males and 43% were females. The main demographic characteristics, co-morbidities, diagnosis and treatment are taken. The most common treatment used is Monocef (ceftriaxone)-34% and Magnex forte (cefperazone+sulbactam)-28%. They belongs to the class of 3rd generation Cephalosporin. Combination of antibiotics like Magnex forte + Azee 6% and Monocef + Azee 12% were most commonly used combinations. In the population 19.5% with hypertension(htn), 3.5% with diabetes mellitus(dm), 6%with hypertension and diabetes mellitus, 11.5% with combinations and 59.5% with no comorbidities were observed. Conclusion:The study was conducted to review and analyze different trends of antibiotics used in individuals suffering from AFI(Acute Febrile Illness). During our study, it was observed that Dengue and Respiratory tract infections were most commonly cause of AFI (Acute Febrile Illness). Monocef (ceftriaxone) and Magnex forte (cefperazone+sulbactam) belonging to the class of 3rd generation Cephalosporin weremost commonly used antibiotics. During the study it was found that majority of the patients were without co-morbidities and were within the age limit of 15-30years. In the patients who were