Present study was conducted to determine the age distribution of patients with prostatic lesions, prevalence of distribution of various prostatic lesions and to study correlation of histopathological types of prostatic lesions with prostate specific antigen (PSA). Materials and Methods: A total 246 prostatic needle biopsies from patients of all age groups were included in the study. After studying the histopathological features, the diagnosis of various types of prostatic lesions was made and Gleason's scoring was done in cases of prostatic carcinoma. Subsequently, a correlation was made between the histopathological diagnosis and serum PSA level. Results: The Mean±Sd of age is 69.7±9.9 years. In pure inflammatory lesions, LGPIN, HGPIN, BPH, and BPH with prostatitis majority had PSA level <4ng/ml. in malignant cases majority had PSA level above 20 ng/ml. Majority of 65 (80.25%) cases of carcinoma prostate were found poorly differentiated (G3-4) followed by 14 (17.28%) cases were moderately differentiated (G2) and least 2 (2.3%) cases were diagnosed well differentiated (G1). There were 0 cases whose Grade cannot be assessed (Gx). Conclusion: Histopathological diagnosis and grading plays an important role in the management of prostatic cancer. For satisfactory management of patient, a high degree of the awareness of the advances along with team approach has become imperative.