Untreated periodontal intrabony defects are associated with increased risk of progression and tooth loss. 1,2 In parallel with remarkable improvements in the surgical management of intrabony defects in a regenerative direction, [3][4][5] Minimally invasive non-surgical therapy (MINST) has emerged as a valid treatment approach leading to clinical and radiographic healing of such defects. 6,7 It is evident that clinical response and complete resolution of surgically treated intrabony defects are affected by defect morphology. In particular, deeper defects, with a narrower angle and increased number of walls, have a tendency to be associated with improved clinical outcomes following surgery. 8 Although it has been suggested that the same may apply to defects treated with MINST, 9 the evidence is a lot more limited, also due to the fact that, by definition, intra-surgical assessment is not feasible in defects treated only non-surgically.The ability to identify defects suitable for specific treatments modalities is very important, with the aim to be able to personalize treatment. In particular, being able to predict the likelihood of achieving important endpoints such as 'pocket closure' 10 or 'composite outcome' 11 could better inform joint decision making between therapist and patient, as well as strengthen treatment strategies.