This study investigated the role of the rs3856806 single nucleotide variant (SNV) on the peroxisome proliferator-activated receptor γ with the development of type 2 diabetes mellitus (T2DM) by conducting a meta-analysis. Relevant studies were searched in PubMed and were selected according to the inclusion criteria. Data were extracted and subjected to analysis using Review Manager 5.4.1. Pooled odds ratios (OR) and 95% confidence intervals (CI) were computed to measure the association of the SNV with T2DM development. Nine studies published in English were retrieved up to October 1, 2021. Homogeneity (I2 = 3%, P = .41) was achieved for the allelic model with significant outcomes (OR: 0.82; 95% CI: 0.76-0.89; P < .00001). Genotypic models also yielded significant associations for the co-dominant, dominant, and recessive models. All genotypic analysis showed homogeneity (I2 = 0-31%, P = .17-0.76) of the pooled outcomes. Our findings suggest that carrying the T allele of the rs3856806 SNV significantly decreases the risk of acquiring T2DM. However, further studies are necessary to support our claims.