BACKGROUND Sickle cell disease is a prevalent and a widely distributed disease in India. It has been found to be associated with multiple complications such as vaso-occlusion and painful crisis. The aim of the study is to assess the status of vitamin D deficiency amongst adult SCD patients. MATERIALS AND METHODS A cross sectional study with appropriate control group was conducted amongst the patients of MY Hospital, Indore. The Sample included 50 cases and 50 controls. Selection of cases was done on the predefined criteria. The cases and controls were selected based on inclusion and exclusion criteria. The participants who consent to participate were included in the study. The information related to clinical, biochemical parameters were obtained from both the groups. Statistical analysis was done using SPSS software. The comparison between the groups was done using Man Whitney U test, Chi square test and correlation was obtained using Spearman's correlation coefficient. RESULTS Results of the study showed presence of vitamin D insufficiency and deficiency amongst 92% of cases. The level of vitamin D showed significant correlation with frequency of painful crisis, blood transfusion and hospitalization. CONCLUSION It can be concluded that level of vitamin D decreases in SCD patients which can lead to complications such as painful crisis. So, vitamin D supplements can be given to such population to improve the condition of SCD patients.

Background: Chronic obstructive pulmonary disease (COPD) was confused with so many diseases but as the knowledge and medical skill advance gradually a dramatic change could be observed about all diseases. Cigarette smoking is a leading cause of COPD. Objective: The study principally aims to compare arterial blood gas analysis among patients having chronic obstructive pulmonary disease and healthy control cases. Methodology: A cross sectional study was conducted in 200 patients attended a department with 100 COPD patients and 100 healthy patients. Based on inclusion and exclusion criteria patients were recruited. All patients were under go through ABG analysis. Informed consent was obtained from each patient. P value less than 0.05 considered statistically significant. Results: The results of present study indicated that there were significantly greater alteration in the blood gases and acid base chemistry, particularly PaO2, PaCO2 in patients who show evidence of various complications mentioned earlier. Conclusion: It has thus been inferred that although COPD patients had pH within the normal range the majority of them had low normal values. This study concluded that all parameters of ABG were statistically significantly deranged in chronic bronchitis, emphysema and chronic bronchitis with emphysema patients.