Background: Indian studies, especially from this part (NCR Region) are scarce in Carpal tunnel syndrome (CTS), the most common entrapment neuropathy. Aim of this study was to analyze clinical and electrophysiological profile in CTS. Materials and Methods: 50 hands (35 patients) with clinical features compatible with CTS were included in the study. Detailed clinical, laboratory and electrophysiological evaluations of patients were done. The patients were followed up to a period of one year. Results: The mean age of patients was 43.5 years with M: F ratio of 15: 38. Symptoms were bilateral in 30% of patients. The most common symptom was numbness sensation in hands, followed by pain while least common was colour change .Sensory loss was observed in 60% while clumsiness was noted in 40% of hands. Thyroid abnormalities were associated with 30% of hands. Mean EPS Grade was 3.32, with the most common electrophysiological abnormality was increase in latency difference between median and ulnar sensory nerves. This was also seen as the only electrophysiological abnormality in 8%. The least common abnormality was un-recordable CMAP. The patients with only a change in the sensory latency responded well to drugs and use of splint. Those who had in addition abnormal CMAP did not respond so well. The patients with thenar atrophy also did not respond well. Conclusion: Carpal tunnel syndrome commonly presents with numbness in both hands with frequently associated hypothyroidism. Electrophysiological abnormalities can help in predicting the therapeutic response and prognosis. Abnormalities of CMAP and presence of atrophy are predictors of poor prognosis.

The hemorrhagic diseases present a complex problem in medicine, for they are often difficult to diagnose and troublesome to manage. Understanding of structure of various coagulation factors and its genetic control, biological and immunological properties has revolutionized the management of coagulation disorders. Hemophilia A occupies a unique position among the hemorrhagic diseases. The present study centers on the critical evaluation of Hemophilia A patients. Attempt was also made to follow the cases carefully in order to study the natural history of disorder and to assess the response on treatment. The major clinical presentation of our patients was due to bleeding into Joints. Knee joint was the most common site of involvement, a major source of distress, incapacitation, and was showing gross deformity in 25% of cases. Recurrent gum bleeding, was a universal complaint and responsible for a sizeable number of hospital visits by hemophiliacs, surpassed only by joint problems in total burden on hemophilic patients. All the hemophiliacs had prolonged KCCT. WBCT was normal in 35% of cases. Thromboplastin generation test confirmed the type of Hemophilia. Factor VIII is expansive and financial constrain was the main limiting factor in treatment of Hemophiliacs. Inj. Factor VIII was given for episodes of bleeding into joints, bleeding into muscle, traumatic bleeding and intracranial bleeding. Acute hemarthroses was treated with factor transfusion and immobilization. For chronic hemophilic arthropathy emphasis was focused on physiotherapy specially in form of active exercises. Difficulty was experienced in continuing the programme because of super imposed episodes of acute bleeding into joint.