Introduction: Zingiberaceae spices are important in diet and are well known for their health promoting effects. However, their effect on modulation of innate immunity is not very well understood. Objective: The effect of two dietary Zingiberaceae spices (ginger and turmeric) on innate immunological parameters was investigated in Lumbricus terrestris. Materials and Methods: Animals fed ad libitum on Lumbricus growth medium supplemented with 0.1% (w/v) and 0.5% (w/v) of spices for 6 days. Relative fold changes in total coelomic cell counts, coelomic cell viability and relative neutrophil-like cell counts were determined in response to spice treatment. Fold changes in nitric oxide, phagocytic activity (PA) and respiratory burst index (RBI) were determined in response to spice treatment relative to control. Effect of spices on suppression of immunological functions in response to treatment with cyclophosphamide (50 mg/ kg-BW) was also evaluated. Results: Our results indicate that dietary supplementation of Zingiberaceae spices significantly increased the coelomcyte number, viability and their differentiation into neutrophil-like cells. An increase in coelomic fluid nitric oxide level in response to dietary supplementation with ginger and turmeric, may explain these effects. Spice treatments also resulted in coelomcytes that had significantly higher PA relative to control. Surprisingly, the RBI increased nonexponentially in response to spice treatments suggesting a potential enhancement in pathogen recognition and antioxidant defenses. Moreover, cotreatment with spices abrogated immunosuppressive effects of CP in L. terrestris and improved immunological functions. Conclusion: Zingiberaceae spices may have beneficial immunomodulatory properties with potential applications in wound healing, antibiotic and cancer chemotherapy.