BACKGROUND Genital Molluscum (GM) is Sexually Transmitted Disease (STD), common in young adults. Will there be any clinical differences including dissemination with HIV status? So, we compared GM clinically in HIV positive and negative patients. MATERIALS AND METHODS 50 patients of GM, 25 in each group of HIV positive and negative were compared in this observational and prospective study. P value less than i.e. < 0.05 was considered as significant association. RESULTS A: HIV positivity was associated significantly in-a) Age: Higher age group (43 years and 28 years respectively) (p-0.000); b) Trunk (p-0.006); c) Face (p-0.001); d) Giant size (p-0.014); e) Infection or ulceration (p-0.038); B: HIV positivity was not associated with Gender (p-0.254). CONCLUSION Presence of molluscii was associated with HIV positivity with trunk, face, giant size and infection/ulceration, which can be a marker of HIV infection. Gender has no association with HIV infection. Thus, clinical presentation of Genital Molluscum differs with the HIV status of patients. Overall dissemination at multiple sites is common in HIV positive group.