In this contribution, we report on the effect of solvents with different boiling points and annealing temperature on the performance of TIPS-pentacene transistors. Several solvents have been used for TIPS-pentacene thin film processing: toluene, chlorobenzene and tetrahydrofuran. To study the influence of solvent and temperature; the electrical parameters of TIPS-pentacene field effect transistor were measured. The highest values of mobilities were 3 7.1 10 − × cm 2 •V −1 •s −1 , 3 4.5 10 − × cm 2 •V −1 •s −1 and 3 1.43 10 − × cm 2 •V −1 •s −1 respectively for TIPS-pentacene field effect transistor using chlorobenzene, toluene and tetrahydrofuran and annealed respectively at 120˚C, 150˚C and 120˚C. We have correlated these electrical performances with AFM images in order to point out the role of morphological properties. It is found that the grain size, and roughness highly affect the electrical parameters.