Intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) is recommended to prevent malaria in pregnancy. Treatment coverage, particularly for three or more doses, is dependent on pregnant women attending antenatal care (ANC) services as scheduled. The StopPalu project pilot tested short message services (SMSs) to remind women of upcoming ANC visits in the Conakry and Kindia regions of Guinea. Health facilities were selected as pilot and comparison facilities. All women who attended an initial ANC visit at a selected facility during the pilot period and had access to a mobile telephone were enrolled. The pilot group was sent an SMS before each appointment. Percentage of attendance and SP distribution were calculated. A log-binomial regression model determined odds ratios. Pregnant women receiving SMS were 48 times more likely to attend all visits and were 12 times more likely to receive all SP doses during pregnancy.