Objective: To determine the epidemiological profile of rheumatic diseases in hospital consultation at the Ignace Deen National Hospital in Conakry (Guinea). Patients and methods: We used a cross-sectional study of participant seen in rheumatologic consultation between November 1, 2016 and November 30, 2017 at the Rheumatology Department of the Ignace Deen National Hospital in Conakry (Guinea). Rheumatic diseases were diagnosed according to the rigorous criteria. Results: We collected 1038 patients including 679 women (65.41%). The mean age of the patients was 49.88 ± 17.47 years with range of 5 and 93 years. Degenerative pathology (644 cases, 62.04%), chronic inflammatory rheumatism and connective tissue diseases (252 cases, 24.27%), periarticular pathology and canal syndromes (91 cases, 8.76%), microcrystalline arthropathies (49 cases, 4.72%), osteopathies (45 cases, 4.33%), and infectious diseases (16 cases, 1.54%) were the main disorders observed during study period. Conclusion: Most of the rheumatic diseases described in the literature have been found. The particuliarity was the relative frequency of inflammatory rheumatism and fracture osteoporosis. However, the further epidemiological studies would be needed to confirm these data.

Objective: Although the discordance in the disease activity scores based on 28 joints (DAS28) has been widely investigated, few data exist among black African (BA) populations. We aimed first to evaluate the correlation and second to assess the concordance between various DAS28 scores in the BA patients with rheumatoid arthritis (RA). Methods: We conducted a multicenter cross-sectional study in adult patients who had RA from Guinea and Cameroon. These patients were diagnosed according to the 2010 ACR/EULAR criteria. Outcome measures were DAS28-ESR and various DAS28-CRP scores. Paired t-test, agreement kappa coefficient, spearman's correlation coefficient, Bland-Altman plots, and ROC curves were used to analyze different DAS28 scores. Results: Of 74 patients analyzed, 85% were female, mean age of these patients was 50 years, and median disease duration was 36 months (IQR: 12-90). Four DAS28 scores comparisons were performed. DAS28-ESR was on average higher than standard DAS28-CRP (Δ = 0.58, [95% CI: 0.45-0.71]; p < 0.0001) and DAS28-CRP without patient's global VAS assessment (Δ = 0.51 [0.46-0.75]; p < 0.0001). Correlation between DAS28 scores was moderate ranging from 0.6 to 0.82. Overall agreement was lower for the conventional DAS28-ESR (weighted kappa: Range, 37.3% to 55.3%) than Castrejon DAS28-CRP (72.6% to 87.1%). DAS28-CRP-3 has a higher predictive power to evaluate disease activity than DAS28-ESR-3 (AUC, 0.97 [0.95-1.00] vs. 0.80 [0.68-0.91], p = 0.0062). Conclusion: The current study provides information on correlation and discrepancy between different disease activity scores in BA patients with RA, and suggests that these markers were not interchangeable.

INSERM, U1137-IAME, Département de biostatistique, investigations cliniques et pharmaceutiques des maladies infectieuses,

INSERM, U1137-IAME, Département de biostatistique, investigations cliniques et pharmaceutiques des maladies infectieuses,