At the end of 2019, a new category of infectious virus that had never been identified in humans emerged, namely severe acute respiratory syndrome (SARS-CoV-2) or COVID-19. South Korea emerged as one of the few countries that was applauded for their success measurement in the COVID-19 handling. Many analysts and commentators attributed the success to the relations between South Korea’s government and non-profit organizations relations in the country. This article will discuss the supplement, complement, and adversary models in non-profit organizations and state relations in handling COVID-19 in South Korea. Data were taken by using qualitative research methods with a literature study approach derived from books, journals, government and community reports, media, and regulations. The findings show that there is a multilayered relationship between the three models that equip each other and widely found from the first wave of COVID-19 to the fourth wave.