Searching new antioxidants compounds to prevent or reduce the impact of oxidative stress on cells, we designed and synthesized several N-acylhydrazone derivatives with dibenzo[a,d][7]annulene moiety. In this work, a series of previously synthesized N-acylhydrazone derivatives bearing 5H-dibenzo[a,d][7]annulene moiety 7a-g were evaluated for antioxidant activity effect, using the DPPH method. The highest antioxidant activity was exhibited by the compound 7f containing in his molecule 4-hydroxy-3-methoxyphenyl fragment.