Achieving optimal pain control following TKA remains a challenge, given its subjective nature and patient variability. As a result, it is difficult to devise a "one fits all" analgesic regimen. In this analysis, were viewed the use and efficacy of different modes of perioperative analgesia. The purpose of this review is to present the new protocols and classic strategies for the management of pain in the post-operated patient of total knee replacement as well as the multimodal analgesia regimen which has been widely used in recent years.