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BackgroundFactor V Leiden polymorphism is a well-recognized genetic factor in the etiology of preeclampsia. Considering that Ghana is recording high incidence of preeclampsia, we examined if factor V Leiden is a contributory factor to its development and pregnancy outcomes.MethodsSTROBE consensus checklist was adopted to recruit eighty-one (81) consenting subjects after ethical clearance. Subjects were followed up till delivery to obtain outcomes of PE. Routine blood chemistry and proteinuria were done on all samples. Factor V Leiden was characterized by polymerase chain reaction and restriction fragment length polymorphism (RFLP). The data was captured as protected health information (PHI) and analyzed with SPSS version 22.ResultsOverall allelic frequencies found in FVL exon 10 were 0.67 and 0.33 for G and A alleles respectively. The FVL mutation was more in PE and hypertensive patients. Increased white blood cells, increased uric acid and a three – fold increment of AST / ALT ratio was observed in PE cases when stratified by FVL exons (exon 8 and 10). Significant differences were also observed between FVL and age, systolic blood pressure (SBP), diastolic blood pressure (DBP), liver enzymes, white blood cells (wbc), hemoglobin levels.ConclusionFVL mutation allele frequency was 0.33, a first report. The mutation was associated with increased uric acid, liver enzymes and blood cell indices suggestive of acute inflammation.

Background: Over the past decade there has been an increased focus on the link between the history of preeclampsia and cardio metabolic syndrome -a danger signaling event. The impact of this event is now becoming alarming in developing countries but data is scanty. Hence the need to collate information in Ghana.Aim: To compare cardio metabolic profile of preeclampsia before and after 34 weeks in Ghana Methodology: The nested case control study was located at the Obstetrics and Gynecology department of the Korle-Bu Teaching Hospital (KBTH). One hundred and sixty-four (164) consented subjects were recruited after ethical clearance was obtained and structured questionnaire administered to them. Four (4) ml blood and 5 mL urine samples were taken for biochemical analysis and urinalysis respectively. Randox automated chemistry analyzer was used to quantify blood chemistry. The data was captured as protected health information (PHI) and analyzed with SPSS version 18. Results:In preeclampsia, increased cardio metabolic scores before term were associated with low birth weight while lactate dehydrogenase (LDH) increased before 34 weeks and rather decreased after 34 weeks. Systolic blood pressure (SBP), white blood cells (WBC) and aspartate transaminase (AST) increased as well in PE clients while platelet (PLT), low density lipoprotein (LDL) and birth weight decreased when these variables were doubly stratified by weeks of gestation and cardio metabolic profile. Conclusion:Among preeclampsia, increased cardio metabolic profile before term were associated with low birth weight.