BackgroundObesity is common among children and teenagers and is associated with cardiometabolic risk factors in the adult age. The objective of this paper was to evaluate the association between the percentage of body fat and cardiometabolic risk factors in children and adolescents in the city of Bucaramanga, Colombia.Material and MethodsAbout 494 children and adolescents aged 10–20 years were studied. Laboratory tests were made for analyzing cardiovascular risk factors and anthropometric measurements. Percentage body fat was determined with Slaughter equation. Lineal regression analyses were conducted to evaluate the association between cardiometabolic risk factors and the percentage body fat.ResultsPrevalence of percentage body fat (>26%) was 46.1%. Variables associated with percentage body fat were HOMA-IR – insulin resistance, HDL, LDL, triglycerides, and total cholesterol levels, and high blood pressure.ConclusionsIncrease in percentage body fat is significantly associated with cardiometabolic risk factors in children and adolescents in Bucaramanga. Early identification and intervention of this population at risk is fundamental.

The objective of the present study was to evaluate the efficacy of oral administration of vitamin D supplementation in reducing BMI and lipid profile in adolescents and young adults from a cohort in Bucaramanga, Colombia. One hundred and one young adults were randomly assigned to one of two doses of vitamin D [1000 international units (IU) or 200 IU] administered daily for 15 weeks. The primary outcomes were serum 25(OH)D levels, BMI and lipid profile. The secondary outcomes were waist-hip ratio, skinfolds and fasting blood glucose. We found a mean ± sd plasma concentration of 25-hydroxyvitamin D [25(OH)D] was 25⋅0 ± 7⋅0 ng/ml at baseline, and after 15 weeks, it increased to 31⋅0 ± 10⋅0 ng/ml in the participants who received a daily dose of 1000 IU, (P < 0⋅0001). For the participants in the control group (200 IU), it went from 26⋅0 ± 8⋅0 ng/ml to 29⋅0 ± 8⋅0 ng/ml (P = 0⋅002). There were no differences between groups in body mass index. There was a statistically significant decrease in LDL-cholesterol between the intervention group v. the control group (mean difference −11⋅50 mg/dl (95 % CI −21⋅86 to −1⋅15; P = 0⋅030). The conclusions of the present study were two different doses of vitamin D supplementation (200 IU v. 1000 IU) produced changes in serum 25(OH)D levels over 15 weeks of administration in healthy young adults. No significant changes were found in the body mass index when the effect of the treatments was compared. A significant reduction in LDL-cholesterol was found when comparing the two intervention groups. Trial registration: NCT04377386

Background: In recent years, the role of vitamin D (VD) as a protective factor in cardiovascular disease has been recognized. Thus, there is a need to study the effect of vitamin D supplementation in the control of different cardiovascular risk factors and metabolic syndrome, especially in young populations where few studies have been conducted. Methods: Pilot study of a randomized, parallel two-arm, triple-blind clinical controlled trial in 150 adolescents and young adults in the city of Bucaramanga-Colombia. The intervention group will receive 1000 IU of VD and the control group 200 IU of VD daily for 15 weeks. The main outcomes are: serum calcifediol levels (25(OH) D), body mass index and lipid profile; secondary outcomes are complementary to the previous ones (skin folds, waist-hip ratio). Other variables will be analyzed such as assessment of dietary intake, physical activity, sun exposure, cigarette and tobacco consumption and compliance with VD supplementation. Discussion: This study is innovative since there is little evidence from clinical trials in adolescents and young adults; similar studies are not known in our context. The results of this study may facilitate the recommendation of oral vitamin D supplementation in the population of interest. In addition, it is a low-cost and easy-to-apply intervention that could contribute to the formulation and implementation of health policies. Trial registration: NCT04377386

Objetivo: describir mediante la aplicación de minería de datos quién desarrolla obesidad y síntomas depresivos (SD) en la población adolescente de la ciudad de Bucaramanga. Métodos: a través de un estudio descriptivo y transversal anidado en una cohorte poblacional. Se evaluaron 432 adolescentes. Se captó información de variables sociodemográficas, SD y medidas antropométricas. Se llevaron a cabo análisis estadísticos para variables categóricas y continuas, así como un análisis de minería de datos. Resultados: el 26.7% de los adolescentes presentó exceso de peso. Se observó que más de la mitad de la muestra presentó SD. El análisis de minería de datos permitió identificar seis grupos de participantes de acuerdo con sus características con relación al peso y a los SD. Conclusiones: la relación entre SD y obesidad se estableció en el grupo de mujeres adolescentes, observándose que aquellas con un peso mayor a 2 desviaciones estándar presentaban todos los SD.

Objetivos: Determinar la incidencia de infección por SARS-CoV-2 en trabajadores de la salud de primeria línea de atención para COVID-19, con esquema completo de la vacuna ARNm BNT162b2, y correlacionar con la seroconversión evaluada con títulos de IgA, IgM e IgG. Métodos: Se evaluaron 245 individuos de una institución de salud de alta complejidad en Bucaramanga, Colombia. Se obtuvieron muestras de hisopados nasofaríngeos para la detección molecular de SARS CoV-2 con kits comerciales de diagnóstico molecular eDiagnosis® y con el sistema de detección CFX96TM BioRad® y Gentier96® mediante PCR en tiempo real, y muestras de sangre para evaluar seroconversión utilizando kits de prueba cualitativa y cuantitativa AESKULISA® SARS-CoV-2 S1 NP IgA, IgG e IgM contra el dominio S1 de la proteína Spike glicosilada del SARS-CoV-2. Resultados: En 11 participantes (5 %), se logró identificar por RT-PCR infección por SARS-CoV-2 posterior al esquema completo de inmunización, nueve de ellos (81,8 %) se hicieron la prueba porque tenían síntomas, y cuatro (44,4 %) manifestaron que algún compañero laboral había sido diagnosticado con COVID-19. La mediana de tiempo entre la segunda dosis de inmunización con BNT162b2 y el inicio de los síntomas fue de 60 días (rango 27-149). Todos los casos positivos presentaron una buena seroconversión en todas las inmunoglobulinas, especialmente para IgG. Conclusiones: Nuestros datos demuestran que, en general los trabajadores de la salud de primera línea de atención para COVID-19 tienen buena respuesta de anticuerpos a la vacuna de ARNm BNT162b2. No obstante, el 5 % de la población tuvo infección por COVID-19. Todos los individuos infectados tuvieron manifestaciones leves a moderadas o fueron asintomáticos.