Problem of an natural organic systems origin -amino acids, nucleotides and other construction elements of life and also natural hydrocarbonic systems to which oil and gas belong is actual not only with fundamental, but also from the practical point of view. We know that hydrocarbonic resources of a planet are steadily exhausted. At present there are not methods and models to calculate the resources of oil and life-related molecules in interstellar environment. In this paper is developed the mathematical model of the molecules composition distribution in the interstellar environment on thermodynamic potentials using methods of the probability theory, the mathematical and physical statistics and the equilibrium thermodynamics. Based on this model are estimated the resources of life-related molecules, amino acids and the nitrogenous bases in the interstellar medium. The possibility of the oil hydrocarbons molecules formation is shown. The given calculations confirm Sokolov's and Hoyl's hypotheses about the possibility of the oil hydrocarbons formation in Space. Results are confirmed by data of astrophysical supervision and space researches.