While many cancer centers suggest treating pain with medication and nondrug treatment, few include the use of virtual reality (VR) as an alternative for stress and pain relief therapy. The purpose of this research was to determine whether a nature-inspired VR simulation reduced stress and pain levels among patients in a cancer treatment center. Using a repeated measures design, 50 patients attending their regularly scheduled chemotherapy infusion were measured for pain and stress during their intravenous (IV)/port access. At the patient’s second visit, they viewed a nature-inspired VR simulation while receiving their IV/port access and were measured for pain and stress again. The paired, one-tailed t tests found significant increases in relaxation, feelings of peace, and positive distractions. While patients felt significantly less frustrated, measures for stress and pain were not significant. Future research should include additional stress and pain measures to determine the viability of VR for chemotherapy infusions.