Late-onset painful sensory neuropathies are usually acquired conditions associated with common diseases. Adult presentations of known hereditary forms are often accompanied by other organ involvement. We recruited a large French-Canadian family with a dominantly inherited late-onset painful sensory neuropathy. The main clinical feature is recurrent leg pain that progresses to constant painful paraesthesias in the feet and later the hands. As it evolves, some patients develop a mild sensory ataxia. We selected four affected individuals for whole exome sequencing. Analysis of rare variants shared by all cases led to a list of four candidate variants. Segregation analysis in all 45 recruited individuals has shown that only the p.Ile403Thr variant in the α-N-acetyl-glucosaminidase (NAGLU) gene segregates with the disease. Recessive NAGLU mutations cause the severe childhood lysosomal disease mucopolysacharidosis IIIB. Family members carrying the mutation showed a significant decrease of the enzymatic function (average 45%). The late-onset and variable severity of the symptoms may have precluded the description of such symptoms in parents of mucopolysaccharidosis IIIB cases. The identification of a dominant phenotype associated with a NAGLU mutation supports that some carriers of lysosomal enzyme mutations may develop later in life much milder phenotypes.
-Rebar tying is labor-intensive and expensive, with a high learning curve that restricts proficiency at the craft to a great deal of construction field experience. Obtaining this experience requires tasks that are taxing on the human body, often resulting in muscular and skeletal injuries. Previously, research and engineering controls for rebar tying/rod busting have been reasonably limited. The main contribution of this study is investigating the use of a new advanced technology to reduce the time, cost, and hazard associated with rebar tying. Hence, several experiments were conducted on the effectiveness of an automatic rebar tying gun by comparing the speed and cost effectiveness of this tool with the common industry practice of manually tying rebar with a spool of wire and pliers. The study results show that the automatic rebar tying gun could lower the learning curve, thereby reducing training times and minimizing redundant routines. By minimizing the amount of time invested in training employees, the possibility of saving time and money is apparent. However, risk reduction is also implied by the lessening of time invested in training employees. This is because resignations frequently happen before a return on the investment of training is produced, resulting in sunk costs. Various repetitive, often manual, movements required of workers have been observed to be reduced from the use of the rebar tying gun. The results of this study also shows that the automatic rebar tying gun has a potential to save time, money, and ergonomic liabilities without risking productivity.
No abstract
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.