This case chronicles an impoverished family inBihar that has experienced the destructive effects of Visceral Leishmaniasis (VL) with neighbours and family. The family lives in fear for the health and wellbeing of their children. The case outlines the unique needs of a population affected by a neglected disease for which there is no market for a cure in the developed world, and therefore a lack of incentive to develop an effective and cost-efficient treatment. Owning to her professional background in both public and private enterprises, along with her personal desire to make a difference, this case study also chronicles the inspirational brainchild of Victoria Hale, PhD, her husband, Ahvie Herskowitz, MD, the Institute of OneWorld Health (iOWH), and a relationship building of non-typical publicprivate partnership. This case highlights the need for a unique partnership, outlines the struggles in launching one, and the ensuing challenges faced in maintaining funding for a development project that will not see fruition for several years.