No abstract

Using exact enumeration technique, we studied the eect of asymmetry arising due to the cone-shaped channel on the DNA melting. We calculate the free-energy barrier arising due to this asymmetry, and its dependence on the base-pair interaction (say, solvent of dierent dielectric constants) across the interface. We also calculate the equilibrium properties of DNA to analyse the eect of base-pair interactions and nature of pore (cone versus flat) on dsDNA chain attached at varying distances from the edge of a pore. The simple model presented here captures the essential physics of transfer of dsDNA across the interface of the confined geometry.

No abstract

We study dsDNA (double strand DNA) melting in detail within varying strip-like confinement in a two-dimensional lattice model. The interplay between reduced configurational entropy and attractive base-pairing energy results non-monotonic...