ObjectiveTo determine the efficacy and safety of azithromycin 1.5% eye drops in a paediatric population with purulent bacterial conjunctivitis.Patients and methodsThis was a multicentre, international, randomised, investigator-masked study in 286 children with purulent discharge and bulbar conjunctival injection. Patients received either azithromycin 1.5% eye drops (twice daily for 3 days) or tobramycin 0.3% eye drops (every 2 h for 2 days, then four times daily for 5 days). Clinical signs were evaluated on day (D) 0, 3 and 7, and cultures on D0 and D7. The primary variable was the clinical cure (absence of bulbar conjunctival injection and discharge) on D3 in the worse eye for patients with positive cultures on D0.Results286 patients (mean age 3.2 years; range 1 day–17 years) were included; 203 had positive cultures on D0. Azithromycin was superior to tobramycin in clinical cure rate on D3 (47.1% vs 28.7%, p=0.013) and was non-inferior to tobramycin on D7 (89.2% vs 78.2%, respectively). Azithromycin treatment eradicated causative pathogens, including resistant species, with a similar resolution rate to tobramycin (89.8% vs 87.2%, respectively). These results were confirmed in a subgroup of patients younger than 24 months old.ConclusionsAzithromycin 1.5% eye drops provided a more rapid clinical cure than tobramycin 0.3% eye drops in the treatment of purulent bacterial conjunctivitis in children, with a more convenient twice-a-day dosing regimen.
Résumé Dans les analyses des formes de travail post-tayloristes, il n’est pas rare de constater que les rituels de manifestation de la reconnaissance qui y sont pratiqués sont fréquemment à l’origine de sentiments d’humiliation et d’absence de considération. Ils résultent de formes de reconnaissance instrumentalisantes et standardisantes qui échouent à répondre aux attentes de reconnaissance concrètes de la part des travailleurs, et qui, souvent, se démentent elles-mêmes performativement. Il ne faut donc pas, ici, se hâter de caractériser ces nouvelles attentes de reconnaissance comme des phénomènes régressifs d’indifférenciation, mais les prendre au sérieux en tant que signes de processus de transformations structurelles du monde du travail.
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