In the setting of the coronavirus disease 2019 (COVID-19) pandemic, only few data regarding lung pathology induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is available, especially without medical intervention interfering with the natural evolution of the disease. We present here the first case of forensic autopsy of a COVID-19 fatality occurring in a young woman, in the community. Diagnosis was made at necropsy and lung histology showed diffuse alveolar damage, edema, and interstitial pneumonia with a geographically heterogeneous pattern, mostly affecting the central part of the lungs. This death related to COVID-19 pathology highlights the heterogeneity and severity of central lung lesions after natural evolution of the disease.

Chordoma is a rare tumor of notochordal origin, currently principally treated by surgery and/or irradiation. Here, we describe the clinical outcome of 3 consecutive patients with metastatic and locally advanced chordoma, treated with different immunotherapeutic approaches. All patients presented fast growing tumors and failure of standard therapies. One was treated with a tumor-based vaccine, the 2 others with anti-PD1 antibodies, all with impressive clinical and radiological responses. We therefore propose that chordoma is an immunogenic tumor and thus that translational and clinical research is necessary to develop rationally designed immunotherapy approaches.

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In the setting of COVID-19 pandemic, only few data regarding lung pathology induced by SARS-CoV-2 is available, especially without medical intervention interacting with the natural evolution of the disease. We present here the first case of forensic autopsy of a COVID-19 fatality occurring in confinement and in a young female. Diagnosis was made at necropsy and lung histology revealed diffuse alveolar damage, edema and interstitial pneumonia with a geographically heterogeneous pattern, affecting mostly central part of the lungs. This death related to COVID-19 pathology highlights the heterogeneity and severity of central lung lesions when the disease naturally evolves.

Among the different research methods on suicide notes, the theoretical conceptual approach allows a particularly thorough understanding of the suicidal act. The present study focuses on 78 suicide notes collected in Geneva, Switzerland, between 2006 and 2014. The socio-demographic and medical data of the writers' notes were collected. The conceptual content of the notes was analyzed by two independent raters using the Leenaars method. The results showed that the concepts that appeared most frequently in the notes were: Inability to adjust, Rejection-aggression, Unbearable pain, and Ego. Very few differences were found in the conceptual content when stratified for age, gender, socio-economic status, or religion. This study confirms and complements the findings of similar studies on the content of suicide notes.