Can microbiota modulation prevent the development of fatty liver disease? The work described in this article is part of the Marie Skłodowska-Curie Innovative Training Network “Building a Gut Microbiome Engineering Toolbox for In-Situ Therapeutic Treatments for Nonalcoholic Fatty Liver Disease”. We aim to develop new microbial therapies for the treatment of non-alcoholic fatty liver disease (NAFLD). Various strains from the Bacteroidetes phylum were investigated for beneficial traits protecting against NAFLD.